Order NO. D126174
產品描述
概述
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
應用
酶聯免疫吸附測定（ELISA），免疫印跡（WB），免疫組織化學（IHC）
屬性
| 保存緩衝液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 運輸條件 |
2-8°C
|
| 靶點 Uniprot 登記號 |
Q9H6E4
|
| 靶點基因 ID |
79879
|
| 靶點全稱 |
coiled-coil domain containing 134
|
| 靶點研究領域 |
Signal Transduction
|
| 亞型 |
Immunogen-specific rabbit IgG
|
